Today I was not able to save anymore images in PainShop Pro as jpg (png will work). PainShop Pro will simply freeze if I try to do this.
The issue: a clipboard monitor called PureText was conflicting with PainShop Pro. Closing the program solved the issue.
I have no clue why the programmers of PainShop Pro chose to hook to the clipboard while saving the output as JPG but obviously is not only pointless but also poorly implemented.
Case solved.